Children aged 2–6 years who require general anesthesia for surgery
Conditions
Interventions
Non-obese group:The ciprofol dose for each patient was determined using the modified Dixon up-and-down sequential method. The starting dose for the first patient was 0.6 mg/kg, based on the literature
the ciprofol induction dose for the subsequent patient was increased by 0.05 mg/kg.
Obese group:The ciprofol dose for each patient was determined using the modified Dixon up-and-down sequential method. The starting dose for the first patient was 0.6 mg/kg, based on the literature, wi
Sponsors
The First People's Hospital of Yancheng
Eligibility
Sex/Gender
All
Age
2 Years to 6 Years
Inclusion criteria
Inclusion criteria: 1. Age 2–6 years; 2. BMI between the 5th and 85th percentiles for age- and sex-matched children (non-obese group), or =95th percentile for age- and sex-matched children (obese group); 3.Children with ASA physical status I–II who require general anesthesia.
Exclusion criteria
Exclusion criteria: 1. Known hypersensitivity to ciprofol or other anesthetic agents; 2. Upper respiratory tract infection, uncontrolled asthma, or suspected difficult airway; 3. Hepatic and/or renal dysfunction; 4. Current use of antiepileptic drugs, sedatives, etc; 5. Neurodevelopmental delay.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The median effective dose (ED50) of ciprofol for successful induction in the two groups; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of respiratory depression;Incidence of laryngospasm;Incidence of hypotension;Incidence of bradycardia;Incidence of postoperative nausea and vomiting;Length of stay in the PACU (Post-Anesthesia Care Unit); | — |
Countries
China
Contacts
Public ContactLiu Xiang
The First People's Hospital of Yancheng
Outcome results
None listed