AWS
Conditions
Interventions
Diazepam group:Patients in the diazepam group were treated with oral diazepam, following the fixed dosing regimen until the CIWA-Ar score was <=8 points, and then the medication was stopped.administra
The oxazepam group:Patients in the oxazepam group were treated with oral oxazepam, following the fixed dosing regimen until the CIWA-Ar score was <=8 points, and then the medication was stopped.
Sponsors
The Second Xiangya Hospital, Central South University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Inpatients; Aged 18 to 70; 2. Meet four or more of the DSM-5 diagnostic criteria for alcohol use disorder; 3. Currently in the withdrawal period with a CIWA-Ar score of >=16 points; 4. The doctor assesses that benzodiazepines are suitable for treatment. 5. Sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Combined with other substance dependencies (except nicotine); 2. Impact assessment of severe mental disorders or cognitive impairments; 3. Pregnancy or lactation period; 4. Allergic to or contraindicated to the investigational drug; 5. ALT or AST>500; 6. New York Cardiac Rating (NYHA) rating >= level 3; 7. Patients with a history of HIV infection or autoimmune deficiency; 8. Inability to cooperate with follow-up or deemed inappropriate by the researcher.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in CIWA-Ar score and time to reach a score of <=8; | — |
Secondary
| Measure | Time frame |
|---|---|
| Trends in liver function indicators; | — |
Countries
China
Contacts
Public ContactHao Wei
The Second Xiangya Hospital, Central South University
Outcome results
None listed