chronic pain complicated with cognitive dysfunction
Conditions
Interventions
chronic pain and cognitive dysfunction group:None
chronic pain without cognitive dysfunction group:None
control group:None
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Chronic pain with cognitive dysfunction group 1. Voluntarily participated in this study and signed the informed consent form, and those who did not participate in other clinical trials; 2. Age greater than 18 years old, BMI 18.5 - 23.9 kg/m^2, gender not limited; 3. Duration of pain >= 3 months, Numerical Rating Scale (NRS) = 1; 4. Montreal Cognitive Assessment Scale (MoCA) score = 1; 4. The Montreal Cognitive Assessment Scale (MoCA) score is > 26 points; Healthy control group 1. Voluntarily participated in this study and signed the informed consent form, and those who did not participate in other clinical trials; 2. Age is > 18 years old, BMI is 18.5 - 23.9 kg/m^2, gender is not limited; 3. Healthy individuals without chronic pain and cognitive impairment;
Exclusion criteria
Exclusion criteria: 1. Patients who have taken antibiotics, steroids and other hormones, herbal preparations (including oral, intramuscular injection or intravenous injection), microecological preparations, hormones or other drugs or preparations that affect the intestinal flora within the past 3 months; 2. Patients who have significantly changed their diet structure in the past 1 month; 3. Patients with a history of surgery or stress trauma in the past 1 month; 4. Patients with intestinal diseases or diarrhea excluded; 5. Patients with infectious diseases, autoimmune diseases, metabolic diseases, tumors, etc.; 6. Patients who cannot obtain stool specimens within 2 days after admission; 7. Patients with a history of neurological or mental disorders, including but not limited to dementia, Alzheimer's disease, cerebral ischemia, brain injury, central infection, epilepsy, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, spinal cerebellar ataxia, severe anxiety disorder, severe depression, schizophrenia, etc.; 8. Women in special periods such as pregnancy or lactation, or with special dietary habits such as ketogenic diet, dieting, vegetarianism; 9. Patients who cannot cooperate in pain and cognitive scoring, and the researchers consider that there are any reasons preventing them from being included.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gut microbiota;Plasma metabolites; | — |
Countries
China
Contacts
Public ContactChan Chen
West China Hospital, Sichuan University
Outcome results
None listed