Post-stroke depression
Conditions
Interventions
Post-stroke depression (PSD) group:none
No post-stroke depression group:none
Sponsors
Affiliated Hospital of Xuzhou Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.All patients with acute stroke hospitalized in the neurology department of the hospitals participating in this study in 2024; 2.The patient meets the diagnostic criteria for stroke in the Fourth Chinese Cerebrovascular Disease Academic Conference, with imaging lesions shown on brain CT or MRI, and is accompanied by sudden clinical symptoms of global or focal neurological deficits lasting for more than 24 hours; 3.The stroke assessment scale uses the National Institutes of Health Stroke Scale (NIHSS). An NIHSS total score of 0-1 indicates normal or near-normal; 1-4 indicates mild stroke, 5-15 indicates moderate stroke, 15-20 indicates moderate to severe stroke, and 20 or higher indicates very severe stroke. Patients with a score below 12-14 have an 80% chance of a good outcome, while those with a score above 20-26 have a less than 20% chance of a good outcome; 4.Including cerebral infarction, cerebral hemorrhage and cerebral infarction with symptom relief after thrombolysis; 5.The time from stroke onset to hospitalization should not exceed 14 days; 6.Be willing and have sufficient cognitive ability to complete all procedures for data collection and subsequent follow-up steps; 7.Agree to sign the informed consent form and retain relevant blood samples, stool samples and brain imaging data for subsequent experimental purposes.
Exclusion criteria
Exclusion criteria: 1.Patients with a history of mental illness such as depression, anxiety, dementia, etc., with a Hamilton Depression Rating Scale (HAMD) score greater than or equal to 7 points upon admission, or those who have taken relevant antidepressants and other antipsychotic drugs and instrumental treatments; 2.Behavioral and cognitive function problems or impairments prevented the completion of this study and subsequent follow-up surveys. All subjects were given a simple cognitive function test using the Minimum Mental State Examination (MMSE). Those with a score of less than 20 (moderate or severe cognitive impairment) were excluded; 3.Have other mental illnesses; 4.Neurological impairment caused by other reasons, such as brain tumors; 5.TIA and subarachnoid hemorrhage; 6.Those who developed other major diseases during the follow-up and were unable to continue the investigation or died.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hamilton Depression Scale score;Inflammatory factor indicators;Short-chain fatty acid index;Free fatty acid index;16S rRNA of fecal bacteria; | — |
Secondary
| Measure | Time frame |
|---|---|
| Minimum Mental State Examination score;The National Institutes of Health Stroke Scale score;Modified Rankin Scale score;Montreal Cognitive Assessment score;Hamilton Anxiety Scale score; | — |
Countries
China
Contacts
Public ContactShiguang Zhu
Affiliated Hospital of Xuzhou Medical University
Outcome results
None listed