Breast cancer
Conditions
Interventions
N:Undergo neoadjuvant chemotherapy regimen
C:No intervention measures
Sponsors
Weifang Municipal People's Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Age 18–65 years, female. ASA classification I–II. Signing of informed consent.
Exclusion criteria
Exclusion criteria: Allergy to propofol, lipid emulsion, or their excipients. Severe cardiac, pulmonary, hepatic, or renal insufficiency. Long-term use of sedative-hypnotics, opioids, or psychotropic medications. Difficult airway. Neurological disorders or cognitive impairment rendering the patient unable to cooperate with assessment. Pregnant or breastfeeding women. Serious adverse events occurring during the study, deemed unsuitable for continued participation following assessment. Voluntary withdrawal by the patient. Significant deviation from the anaesthetic induction protocol.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The ED50 and ED95 values for phenytoin causing loss of consciousness; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood pressure;Oxygen saturation;Bifrequency Index of Electroencephalogram;Heart rate; | — |
Countries
China
Contacts
Public Contactjifanceng
Weifang Municipal People's Hospital
Outcome results
None listed