Infertility
Conditions
Interventions
control group:The patient does not take any supplements other than folic acid.
Intervention group:Oral administration of taurine (3.2 g daily) is initiated on menstrual cycle days 2–3, one month prior to the start of the controlled ovarian stimulation cycle
Sponsors
Reproductive Medicine Center, the 901th Hospital of the Joint logistics support Force of People’s Liberation Army
Eligibility
Sex/Gender
Female
Age
35 Years to 43 Years
Inclusion criteria
Inclusion criteria: 1. Patients aged 35 to 43 who underwent IVF/ICSI-ET treatment due to infertility; 2. Meeting the criteria for Poseidon Group 4 of diminished ovarian reserve (AFC < 5, AMH < 1.2 ng/ml); 3. 18.5kg/m^2<=Body Mass Index (BMI)<28 kg/m^2; 4. Full understanding of the study content, voluntary participation, and provision of signed written informed consent.
Exclusion criteria
Exclusion criteria: 1.Those with uncontrollable medical diseases that may interfere with or affect the research results, such as serious liver, kidney, heart, brain diseases; 2.Taking other micronutrients, hormones or other drugs that affect fertility except folic acid within one month; 3.Diagnosis of uncontrolled endocrine or metabolic disorders (e.g., thyroid dysfunction, diabetes mellitus, hyperprolactinemia); 4.Known allergy or hypersensitivity to the investigational products (taurine, Coenzyme Q10) or their excipients; 5. Those who failed to return for follow-up appointments on time, had incomplete medical records, and were lost to follow-up for various reasons.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of day 3 high-quality embryos; | — |
Secondary
| Measure | Time frame |
|---|---|
| Number of oocytes retrieved ;Number of MII oocytes;Number of fertilized oocytes (2PN);Number of day 3 available embryos;anti-Müllerian hormone;Biochemical pregnancy;Clinical pregnancy;Early abortion; | — |
Countries
China
Contacts
Public ContactSu Lin
the 901th Hospital of the Joint logistics support Force of People’s Liberation Army
Outcome results
None listed