Postoperative delirium in elderly male patients undergoing laparoscopic hernia repair
Conditions
Interventions
The intravenous Dex infusion group (DV):10 minutes before anesthesia induction, Dex at a dose of 0.6 µ g/kg was continuously intravenously pumped for 10 minutes, and 0.5 ml of physiological saline was
Dex 1.2 µ g/kg was added to the patients PCIA pump and administered intravenously 48 hours after surgery.
The intranasal Dex drops group (DS):10 minutes before anesthesia induction, Dex 0.6 µ g/kg (1 ml in total, 0.5 ml in each nostril) was administered via nasal drip, and an equal volume of physiological
Dex 0.6 µ g/kg was administered via nasal drip at 8 pm on the night after surgery and the second day after surgery.
The blank control group (DN):10 minutes before anesthesia induction, an equal volume of physiological saline was intravenously pumped (completed within 10 minutes), and 0.5 ml of physiological saline
Sponsors
Yiwu Central Hospital
Eligibility
Sex/Gender
Male
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: (1) Male, aged >=65 years; (2) American Society ofAnesthesiologists (ASA) grade I-III; (3) Body mass index (BMI) 18.5–28 kg/m²; (4) Normal preoperative Mini-Mental State Examination (MMSE) score: >17 for illiterate patients, >20 for primary school education, >22 for secondary school education, and >23 for university education.
Exclusion criteria
Exclusion criteria: (1) History of mental illness, dementia, depression, or use of psychiatric medications; (2) History of heart failure, atrial fibrillation, or stroke; (3) Significant sinus bradycardia, third-degree atrioventricular block, or sick sinus syndrome; (4) Severe adverse reactions to Dex; (5) Difficult airway or abnormal nasal structure.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of POD 3 days after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Sleep quality;Mental state;Postoperative pain;Restore quality;Postoperative adverse reactions;Chronic pain; | — |
Countries
China
Contacts
Public ContactWenqin Lv
Yiwu Central Hospital
Outcome results
None listed