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The causal role of the retrosplenial complex in spatial reference frame transformation and its neuromodulatory effects.

The causal role of the retrosplenial complex in spatial reference frame transformation and its neuromodulatory effects.

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2600118108
Enrollment
Unknown
Registered
2026-02-02
Start date
2025-12-25
Completion date
Unknown
Last updated
2026-02-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

spatial navigation impairment

Interventions

5 Hz Active Stimulation Group (Young Adults):Participants in this group received a 5 Hz differential-frequency stimulation using a temporal interference (TI) stimulation device.
40 Hz Active Stimulation Group (Young Adults):Participants in this group received a 40 Hz differential-frequency stimulation using a temporal interference (TI) stimulation device.
80 Hz Active Stimulation Group (Young Adults):Participants in this group received a 80 Hz differential-frequency stimulation using a temporal interference (TI) stimulation device.
Zero-Difference-Frequency Sham Stimulation Group (Young Adults):Participants in this group received zero-difference-frequency sham stimulation using a temporal interference (TI) device, with only a 30
Active Stimulation Group (Middle-Aged and Older Adults):Apply the most effective differential-frequency active stimulation to this group of participants.
Sham Stimulation Group (Middle-Aged and Older Adults):Participants in this group received zero-difference-frequency sham stimulation using a temporal interference (TI) device, with only a 30-second ra

Sponsors

Southwest University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Young adult participants: (1) Have basic patience and responsibility, and can follow instructions carefully; (2) Normal color vision (no color blindness or color weakness); (3) Right-handed; (4) Physically and mentally healthy, with no history of physical or psychiatric disorders, and no head trauma; (5) Have not participated in other brain stimulation experiments recently; (6) Willing to participate in this study and provide written informed consent. Middle-aged and older adult participants: (1) Score above 22 on the MoCA scale, indicating no obvious cognitive impairment; (2) Normal color vision (no color blindness or color weakness); (3) Right-handed; (4) Physically and mentally healthy, with no history of physical or psychiatric disorders, and no head trauma; (5) Have not participated in other brain stimulation experiments recently; (6) Willing to participate in this study and provide written informed consent.

Exclusion criteria

Exclusion criteria: Exclusion criteria for young adult participants: (1) Presence of physical illnesses, including head trauma; (2) Presence of cognitive or psychiatric disorders; (3) History of psychiatric disorders or family history of psychiatric disorders; (4) History of substance abuse of psychoactive substances; (5) Participation in other brain stimulation experiments recently. Exclusion criteria for middle-aged and older adult participants: (1) Failure to pass the MoCA test, with a score below 22; (2) Presence of cognitive or psychiatric disorders; (3) Presence of physical illnesses, including head trauma; (4) History of psychiatric disorders or family history of psychiatric disorders; (5) History of substance abuse of psychoactive substances; (6) Participation in other brain stimulation experiments recently.

Design outcomes

Primary

MeasureTime frame
accuracy;total reaction time;orientation reaction time;reference frame transformation cost;

Countries

China

Contacts

Public ContactLiu Jiali

Faculty of Psychology, Southwest University

ljl20240108@swu.edu.cn+86 182 8011 2161

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 15, 2026