Mental disease
Conditions
Interventions
Bipolar depression group with attempted suicide:None
Bipolar depression group without attempted suicide:None
External validation group - with attempted suicide:None
External validation group - No attempted suicide:None
Sponsors
the First Affiliated Hospital with Nanjing Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 35 Years
Inclusion criteria
Inclusion criteria: 1. Meets the diagnostic criteria for depressive episode of bipolar disorder as defined by DSM-5; 2. Considering that age is a risk factor for suicidal behavior, this study focuses on patients in early adulthood, so the age range is >=18 and =17.
Exclusion criteria
Exclusion criteria: 1. Magnetic resonance scan for claustrophobia; 2. Accompanied by psychotic symptoms such as hallucinations and delusions; 3. Obvious psychological and physical triggering factors; 4. Has a history of serious physical diseases and brain organic diseases; 5. Those who have received electroconvulsive therapy within half a year.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The gray matter volume of the "prefrontal lobe - cingulate - striatum" circuit;Low-frequency amplitude of the "prefrontal - cingulate - striatum" circuit;Functional connection of the "prefrontal lobe - cingulate - striatum" circuit;Susceptibility genes associated with neural circuit damage;Polygenic risk score;The accuracy rate of the two-layer suicide behavior early warning model; | — |
Countries
China
Contacts
Public ContactTian Shui
the First Affiliated Hospital with Nanjing Medical University
Outcome results
None listed