Threatened miscarriage
Conditions
Interventions
Observation group:None
Sponsors
The First Affiliated Hospital of Wenzhou Medical University
Eligibility
Sex/Gender
Female
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1) women between 18 and 40 years of age; 2) positive blood or urine pregnancy test; 3) intrauterine singleton pregnancy with heart tube pulsation; 4) the gestational age of ultrasound diagnosis was >=6 weeks and <=12 weeks; 5) vaginal bleeding with or without lower abdominal pain or low back pain; 6) cervical closure without rupture of membranes; 7) patients taking or about to take dydrogesterone tablets for treatment; 8) Patients provided written informed consent for study participation.
Exclusion criteria
Exclusion criteria: 1) recurrent miscarriage history (defined as at least 3 consecutive miscarriages); 2) ovulation stimulation using assisted reproductive technology; 3) parental chromosomal abnormalities; 4) severe vaginal bleeding requiring surgical intervention; 5) Vaginal ultrasound showed that the crown-rump length of the fetus was =7 mm without heart tube pulsation; 6) history of hCG or progesterone therapy before enrollment; 7) with severe uterine malformation and uterine fibroids; 8) allergy to study drugs; 9) accompanied by tumors, liver and kidney dysfunction, diabetes, autoimmune diseases, such as systemic lupus erythematosus, systemic sclerosis, rheumatoid arthritis, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ongoing pregnancy rate within 12 weeks of gestation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Proportion of severe vaginal bleeding or severe abdominal pain requiring surgical intervention (pregnancy Within 12 weeks' gestation);Reduced frequency of uterine contractions, abdominal pain relief ratio case; | — |
Countries
China
Contacts
Public ContactFeng Lin
The First Affiliated Hospital of Wenzhou Medical University
Outcome results
None listed