Knee osteoarthritis
Conditions
Interventions
0.25% ropivacaine group (group C):Ultrasound-guided combined femoral nerve-obturator nerve-sciatic nerve block using a total volume of 40 ml of 0.25% ropivacaine
10mg dexamethasone + 0.25% ropivacaine group (group Ds1):Ultrasound-guided combined femoral nerve-obturator nerve-sciatic nerve block using a total volume of 40 ml of 10 mg dexamethasone plus 0.25% ro
20mg dexamethasone + 0.25% ropivacaine group (group Ds2):Under ultrasound guidance, a combined femoral nerve-obturator nerve-sciatic nerve block was performed using a total volume of 40 ml of 20 mg de
20ug dexmedetomidine + 0.25% ropivacaine group (group Dm):Under ultrasound guidance, a combined femoral nerve-obturator nerve-sciatic nerve block was performed using a total volume of 40 ml of 20 µg d
20mg dexamethasone + 20ug dexmedetomidine + 0.25% ropivacaine group (group Ds + Dm):Under ultrasound guidance, a combined femoral nerve-obturator nerve-sciatic nerve block was performed using a total
Sponsors
The First People's Hospital of Yunnan Province
Eligibility
Sex/Gender
All
Age
45 Years to 70 Years
Inclusion criteria
Inclusion criteria: Patients scheduled for total knee replacement under general anesthesia, aged 45-70 years, with ASA classification II-III and body mass index (BMI) between 18-28 kg/m2.
Exclusion criteria
Exclusion criteria: Patients with lower limb motor and sensory dysfunction, history of local anesthetic allergy, severe hepatic or renal dysfunction, lower limb vascular diseases, peripheral nervous system disorders, history of diabetes, infection at the puncture site, long-term opioid use, or mental abnormalities that prevent cooperation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Visual Analog Scale (VAS); | — |
Secondary
| Measure | Time frame |
|---|---|
| Usage of Patient-Controlled Analgesia Pump;Onset time of nerve block;Duration of nerve block;Intraoperative vital signs;Intraoperative drug usage; | — |
Countries
China
Contacts
Public ContactJin Hua
The First People's Hospital of Yunnan Province
Outcome results
None listed