None
Conditions
Interventions
Experimental group:Oxycodone Fumarate Injection
Sponsors
The Affiliated Hospital of Nanjing University of Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >=18 years old, gender not limited. 2. ICU inpatients who need invasive mechanical ventilation. 3. The expected mechanical ventilation time is >=72 hours. 4. The patient's APACHE ? score is >=15 points 5. Sign the informed consent form
Exclusion criteria
Exclusion criteria: 1. Patients with severe traumatic brain injury, neuromuscular disorders, or neurological/cognitive impairment following cardiopulmonary resuscitation. 2. Patients with severe acute respiratory distress syndrome (ARDS). 3. Patients with a history of long-term oral, intravenous, or topical use of other opioid analgesics. 4. Known or suspected gastrointestinal obstruction. 5. Pregnant or breastfeeding women. 6. Allergy to the study drug. 7. Patients with irreversible underlying conditions or those with a prognosis of death within 48 hours, such as advanced malignant tumours.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sedation score, RASS;Analgesia score, CPOT; | — |
Secondary
| Measure | Time frame |
|---|---|
| Sedative dosage;Analgesic drug dosage;Duration of mechanical ventilation; | — |
Countries
China
Contacts
Public ContactTao Guo
The Affiliated Hospital of Nanjing University of Chinese Medicine
Outcome results
None listed