Patients with Trauma Complicated by Acute Lung Injury
Conditions
Interventions
Observation group (Trauma Complicated by Acute Lung Injury):None
Control group:None
Sponsors
Second Affiliated Hospital, University of South China
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age: 18 years = 16); 3. Diagnosis and Timing: Diagnosis of Acute Respiratory Distress Syndrome (ARDS) according to the Berlin Criteria within 24-48 hours after admission, which is the target condition of this study—Acute Lung Injury (ALI); 4. Surgical Intervention: Requirement of emergency or elective surgical intervention due to trauma; 5. Informed Consent: Voluntary provision of written informed consent by the patient or their immediate family member after full understanding of the study details.
Exclusion criteria
Exclusion criteria: 1. History of Pre-existing Pulmonary Disease: Presence of significant chronic respiratory conditions such as chronic obstructive pulmonary disease, interstitial lung disease, pulmonary fibrosis, lung cancer, etc. 2. ALI/ARDS Due to Other Causes: ALI/ARDS caused by non-traumatic direct factors such as pneumonia, aspiration, sepsis, pancreatitis, etc. 3. Severe Immune Dysfunction: Known conditions including AIDS, long-term use of high-dose immunosuppressants or glucocorticoids, ongoing chemotherapy, etc. 4. Coexisting Severe Chronic Illnesses: Including end-stage liver disease, renal failure (requiring long-term dialysis), or chronic heart failure classified as New York Heart Association (NYHA) Class III–IV. 5. Limited Life Expectancy: Presence of irreversible severe traumatic brain injury at admission, or an expected survival time of < 72 hours. 6. Inability to Participate in the Study: Pregnant or lactating women, as well as individuals unable to complete the follow-up procedures required by this study for any reason.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Severity of Pulmonary Injury;28-day all-cause mortality; | — |
Secondary
| Measure | Time frame |
|---|---|
| The levels of various DAMPs in peripheral blood;APACHE II Score;SOFA Score;Total duration of mechanical ventilation;Length of ICU stay; | — |
Countries
China
Contacts
Public ContactRen Jing
Second Affiliated Hospital, University of South China
Outcome results
None listed