None
Conditions
Interventions
Hypertensive disorder complicating pregnancy (HDP) group:None
Normotensive Control Group:None
Sponsors
Ningxia Hui Autonomous Region People's Hospital
Eligibility
Sex/Gender
Female
Age
20 Years to 40 Years
Inclusion criteria
Inclusion criteria: Hypertensive Disorders of Pregnancy (HDP) Group: 1. Term parturients diagnosed with hypertensive disorders of pregnancy. 2. Singleton pregnancy. 3. Age: 20-40 years. 4. BMI: 18.0-35.0 kg/m². 5. ASA physical status classification II-III. Normotensive Control Group: 1. Term parturients without relevant comorbidities (e.g., hypertension, diabetes). 2. Singleton pregnancy. 3. Age: 20-40 years. 4. BMI: 18.0-35.0 kg/m². 5. ASA physical status classification II.
Exclusion criteria
Exclusion criteria: (1) Contraindications to neuraxial anesthesia. (2) Known allergy to local anesthetics or opioids. (3) Fetal distress requiring emergent surgery. (4) Significant hepatic or renal dysfunction (ALT > 2 times the upper limit of normal, Cr > 120 µmol/L). (5) Comorbid cardiac disease or cognitive impairment precluding study cooperation. (6) Patient refusal to participate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Concentrations of fentanyl and bupivacaine in umbilical cord blood (arterial and venous).;Maternal serum concentrations of fentanyl and bupivacaine over time in the HDP group.; | — |
Secondary
| Measure | Time frame |
|---|---|
| Time from administration of intraspinal anesthesia to delivery of the fetus;Neonatal Apgar score;Parameters of neonatal blood gas analysis;NACS score of neonates; | — |
Countries
China
Contacts
Public ContactYe Qingshan, Qiang Li
Ningxia Hui Autonomous Region People's Hospital
Outcome results
None listed