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A retrospective study on predicting the risk of major low anterior resection syndrome in rectal cancer patients after neoadjuvant chemoradiotherapy based on distal margin collagen signature

A retrospective study on predicting the risk of major low anterior resection syndrome in rectal cancer patients after neoadjuvant chemoradiotherapy based on distal margin collagen signature

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600118063
Enrollment
Unknown
Registered
2026-02-02
Start date
2026-02-07
Completion date
Unknown
Last updated
2026-02-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Colorectal cancer

Interventions

Observation group:None

Sponsors

Fujian Medical University Union Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1.Age >= 18 years; 2.Histologically or cytologically confirmed rectal cancer; 3.Completion of standard neoadjuvant chemoradiotherapy and low anterior resection between 2019 and 2021; 4.Complete clinicopathological data, surgical specimens, and postoperative LARS score follow-up records.

Exclusion criteria

Exclusion criteria: 1.Concomitant tumors or history of previous tumors; 2.Pregnancy or lactation; 3.Lack of follow-up information;

Design outcomes

Primary

MeasureTime frame
Major low anterior resection syndrome;—

Secondary

MeasureTime frame
Differences in collagen microstructure between the two groups;—

Countries

China

Contacts

Public ContactYan Jun

Fujian Medical University Union Hospital

yanjunfudan@163.com+86 138 2506 6546

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 15, 2026