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Establishment of a Method for Converting Random Concentrations to Trough Steady-State Concentrations of Neuro-Psychiatric Drugs Based on Last-Dose Timing and Construction of Time-Point-Specific Reference Ranges

Establishment of a Method for Converting Random Concentrations to Trough Steady-State Concentrations of Neuro-Psychiatric Drugs Based on Last-Dose Timing and Construction of Time-Point-Specific Reference Ranges

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600118049
Enrollment
Unknown
Registered
2026-02-01
Start date
2026-02-01
Completion date
Unknown
Last updated
2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None

Interventions

Observation group:None

Sponsors

Hangzhou Seventh People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Age: 18 - 65 years old; 2. Have been continuously taking the target neuro-psychiatric drugs (with single drug treatment) for more than 7 half-lives and reached a steady state; 3. Have no severe complications affecting drug metabolism such as severe liver or kidney dysfunction, cardiovascular diseases, etc.; 4. Have completed two blood concentration samplings within a short period of time, including the standard time (12 - 16 hours) and the non-standard sampling time; 5. Clinical data and blood sampling information are complete.

Exclusion criteria

Exclusion criteria: 1. Use other drugs that affect the metabolism of the target drug simultaneously; 2. There are situations such as non-compliance in medication, inaccurate or incomplete recording of blood collection time, or non-cooperation; 3. The blood samples have problems like hemolysis or contamination, which affect the detection results of the concentration; 4. The clinical data is incomplete, making it impossible to complete the data organization and analysis.

Design outcomes

Primary

MeasureTime frame
Accuracy of conversion formula;Accuracy of interpretation of reference ranges;

Countries

China

Contacts

Public ContactDong Jiezheng

The Seventh People's Hospital of Hangzhou

djzh105@126.com+86 571 85126570

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 7, 2026