Hepatectomy patient
Conditions
Interventions
Experimental group:Personalized PEEP titration based on driving pressure
Control group:Fixed 5 PEEP
Sponsors
Hunan Provincial People's Hospital
Eligibility
Sex/Gender
All
Age
65 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Age =>65 years. 2. Planned elective laparoscopic partial hepatectomy under general anesthesia (including segmental resection, combined segmental resection, hemihepatectomy, etc.). 3. Expected duration of pneumoperitoneum >=2 hours. 4. American Society of Anesthesiologists (ASA) physical status classification I-III.
Exclusion criteria
Exclusion criteria: 1. Suffering from severe chronic obstructive pulmonary disease (COPD), with a severity of GOLD grade 3 or higher. 2. Severe heart failure classified as NYHA class III or above. 3. Previous history of thoracic or abdominal surgery, which is expected to cause significant thoracic adhesions or known diaphragmatic dysfunction. 4. Liver function classified as Child-Pugh class C, or an estimated glomerular filtration rate (eGFR) < 30 mL/min/1.73m². 5. Presence of cognitive impairment, mental illness, or language communication barriers, making it impossible to cooperate with postoperative follow-up assessments.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of atelectasis; | — |
Secondary
| Measure | Time frame |
|---|---|
| Early postoperative diaphragm function recovery rate;Postoperative tube removal time;Incidence of intraoperative hypotension/hypertension events;Postoperative nausea and vomiting (PONV) incidence;Intraoperative blood loss;Intraoperative urine output;Intraoperative fluid input;Drive Pressure;Dynamic lung compliance; | — |
Countries
China
Contacts
Public ContactBingbing Pan
Hunan Provincial People's Hospital
Outcome results
None listed