Chronic Periodontitis
Conditions
Interventions
Healthy control group:None
Case group:None
Sponsors
The First Affiliated Hospital of Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Inclusion criteria for the case group: (1) Meet the diagnostic criteria for "chronic periodontitis" as described in the "Introduction to the International New Classification of Periodontal and Peri-implant Diseases" [8]; (2) Age >= 18 years; (3) Number of remaining teeth >= 20; (4) The patient has not undergone any periodontal-related treatment recently; (5) No dental lesions; (6) The control group has no history of periodontal disease; (7) The patient has given informed consent and signed the informed consent form for this study. Inclusion criteria for the healthy control group: (1) Age >= 18 years; (2) Number of remaining teeth in the mouth >= 20; (3) No history of periodontal disease; (4) Gingival probing depth of the entire mouth <= 3 mm; (5) No bleeding after probing (or the proportion of bleeding points is < 10%); (6) No significant attachment loss or gingival recession; (7) No periodontal treatment, scaling, or implant surgery in the past 6 months; (8) No use of antibiotics, anti-inflammatory drugs, or mouthwashes in the recent 3 months; (9) Has given informed consent and signed the informed consent form for this study.
Exclusion criteria
Exclusion criteria: (1) Including diabetes, bleeding disorders, or other systemic or local infectious and immunological diseases; (2) Those who used anti-inflammatory drugs or antibiotics within the previous 3 months before enrollment; (3) Those who received periodontal treatment, cleaning, or dental implant surgery within the previous 6 months before enrollment; (4) Pregnant or lactating women; (5) Those who used mouthwash in the past 3 months; (6) Those with recent trauma or surgical history. Exclusion criteria for the healthy control group: (1) Having diabetes, bleeding disorders, or any systemic disease that may affect periodontal health (such as immune system diseases, severe osteoporosis, etc.); (2) Having used antibiotics, non-steroidal anti-inflammatory drugs, or other drugs that may affect periodontal conditions within the past 3 months; (3) Having received periodontal treatment, cleaning, or implant-related surgery within the past 6 months; (4) Pregnant or lactating women; (5) Having uncontrolled dental diseases, oral mucosal lesions, or acute oral infections; (6) Having a recent history of oral and maxillofacial trauma or surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Tumor necrosis factor-a,TNF-a;Interleukin-6,IL-6;Interleukin-17,IL-17;Semaphorin3A,Sema3A;Fibroblastgrowthfactor23,FGF-23;High sensitivity C-reactive protein, hsCRP;Cytokine receptor like factor 1,CYTL-1; | — |
Countries
China
Contacts
Public ContactLi Ji
The First Affiliated Hospital of Sun Yat-sen University
Outcome results
None listed