Perioperative intracranial pressure
Conditions
Interventions
Lidocaine high-dose group (L2 group):Lidocaine at a dose of 2mg/(kg·h) is intravenously pumped
Control group (group C):Equal volume sodium chloride injection is intravenously pumped
Lidocaine low-dose group (L1 group):Lidocaine at a dose of 1mg/(kg·h) is intravenously pumped
Sponsors
Ningxia Hui Autonomous Region People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Elective prone position spinal endoscopic surgery under general anesthesia was performed. The surgical types included endoscopic lumbar discectomy, endoscopic posterior approach lumbar interbody fusion, discectomy spinal canal decompression, lumbar laminectomy decompression, etc.; 2. Age >=18 and <=75 years old; 3. The body mass index (BMI) is 18-28 kg/m^2; 4. The ASA classification of the American Society of Anesthesiologists is grade I-II; 5. Have normal cognitive and communication skills.
Exclusion criteria
Exclusion criteria: 1. Has a history of drug allergy to lidocaine; 2. History of concurrent ocular diseases, such as ocular trauma, optic neuritis, optic nerve tumors, retinopathy, glaucoma, cataracts, etc.; 3. Combined with central nervous system diseases and cerebrovascular diseases, such as motion sickness, intracranial infection, cerebrovascular accident, intracranial tumor, etc.; 4. Previous history of eye surgery and ocular trauma; History of craniocerebral trauma and craniocerebral surgery; 5. Combined with severe respiratory, circulatory or endocrine system diseases; 6. Patients with severe liver and kidney dysfunction and coagulation disorders; 7. Limited cervical spine movement or ultrasound suggesting carotid artery plaque formation; 8. Recently taken medications that affect cerebrospinal fluid pressure, such as diuretics and glucocorticoids, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Optic nerve sheath diameter; | — |
Secondary
| Measure | Time frame |
|---|---|
| Intraoperative vital signs;Recovery time for spontaneous breathing;Awakening time;Extubation time;Extubation time;Riker rating;Postoperative VAS pain score;Three day postoperative complications;Occurrence and extent of adverse reactions related to lidocaine (perioral numbness, bradycardia, hypotension);Use of emergency antiemetic drugs;Use of emergency analgesics; | — |
Countries
China
Contacts
Public ContactYe Zhenhai, Song Yuying
Ningxia Hui Autonomous Region People's Hospital
Outcome results
None listed