Rheumatoid Arthritis
Conditions
Interventions
Immune checkpoint inhibitors group:Noners)
Sponsors
The First Affiliated Hospital of Guilin Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age >= 18 years, confirmed malignancy; 2. Diagnosis of rheumatoid arthritis in accordance with the 2010 American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) classification criteria for RA, with the diagnosis confirmed by two rheumatology specialists; 3. have been treated with immune checkpoint inhibitors (PD-1/PD-L1/CTLA-4 inhibitors) or conventional chemotherapeutic agents; 4. have a complete clinical history of at least 12 months and at least 5 follow-up visits in the rheumatology and oncology departments of our centre from the time of RA diagnosis. 5. The diagnosis of rheumatoid arthritis in all patients should meet the 2010 American College of Rheumatology (ACR, American College of Rheumatology)/European League Against Rheumatism (EULAR, The European League Against Rheumatism) classification criteria for RA.
Exclusion criteria
Exclusion criteria: 1. diagnosis of rheumatoid arthritis before the diagnosis of malignancy; 2. severe hepatic and renal insufficiency (Child-Pugh class C or eGFR < 30 ml/min/1.73m²); 3. concurrent treatment with conventional chemotherapeutic agents and immune checkpoint inhibitors prior to the onset of arthritis symptoms; 4. treatment with a biologic agent targeting B-cells, such as rituximab, prior to the onset of arthritis symptoms; 5. loss of follow-up or incomplete key clinical information during follow-up; patients with less than 5 follow-up visits within 1 year from baseline.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| DAS28-CRP; | — |
Secondary
| Measure | Time frame |
|---|---|
| VAS(Visual Analogue Scale for Pain Assessment);C-reactive protein;Average dose of glucocorticoids; | — |
Countries
China
Contacts
Public ContactXu Jia
The First Affiliated Hospital of Guilin Medical University
Outcome results
None listed