Hip diseases
Conditions
Interventions
intervention group:Continuous intravenous infusion of esketamine dilution (concentration: 2.0 mg/mL). Loading dose: administered at a rate of 0.1 mg/kg/h over the initial 10 minutes of infusion
maintenance dose: followed by an infusion rate of 0.2 mg/kg/h until the end of surgery. The total infusion duration should be at least 60 minutes.
control group:An equal volume of normal saline is administered at the same rate and for the same duration.
Sponsors
The 904th Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army
Eligibility
Sex/Gender
All
Age
65 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Age >= 65 years, gender is not limited. 2. patients who are to undergo elective primary unilateral total hip arthroplasty under lumbar anaesthesia. 3. American Society of Anaesthesiologists (ASA) class II or III. 4. Written informed consent signed by the patient or his/her legal representative. 5. No contraindication to intrathecal anaesthesia.
Exclusion criteria
Exclusion criteria: 1. Severe cognitive impairment assessed preoperatively: score on the Brief Mental Status Examination (MMSE), illiterate = 160 mmHg and/or diastolic blood pressure >= 100 mmHg at rest despite antihypertensive medication. 7. History of elevated intracranial pressure, or history of clinically confirmed acute cerebrovascular accident within the last 6 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postoperative delirium; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mean arterial pressure;Duration of surgery;Crystalloid input volume;Any new-onset clinical adverse events occurring within 7 days after surgery, such as infection, cardiovascular/cerebrovascular events, deep vein thrombosis, etc.;Serum interleukin-6 (IL-6) concentrations; | — |
Countries
China
Contacts
Public ContactZhang Longfei
The 904th Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army
Outcome results
None listed