Type 2 diabetes mellitus
Conditions
Sponsors
Hainan General Hospital
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patients with type 2 diabetes mellitus (fasting blood glucose >=7mmol/L or random blood glucose>=11.1mmol/L with typical symptoms of hyperglycemia) or non-diabetic patients 2. Age >=65 years old 3. American Society of Anesthesiologists physical status I-III 4. Body mass index (BMI) <35kg/m² 5. Patients undergoing elective knee surgery 6. The diabetic group should meet the criteria of definite diagnosis of type 2 diabetes mellitus and stable condition. 7. Non-diabetic control group: no history of diabetes, fasting blood glucose and HbA1c were in the normal range. 8. Be able to understand the purpose of the study and sign informed consent
Exclusion criteria
Exclusion criteria: 1. Previous major surgery or structural abnormalities of the stomach, esophagus, or duodenum; Previous gastroparesis was diagnosed; 2. Severe gastroesophageal reflux disease; 3. The history of upper gastrointestinal bleeding in the past 1 month; GCSI (Gastroparesis Cardinal Symptom Index) >=18 (patients with potential gastroparesis were excluded); 4. The use of prokinetic drugs or drugs significantly delaying gastric emptying in the past 2 weeks was not stopped according to the guidelines; 5. Gastroenteritis, vomiting, diarrhea, fever, or any acute illness in the past 2 weeks; 6. Receiving GLP-1 receptor agonist therapy; Recent heavy use of opioid analgesics, anticholinergic drugs, tricyclic antidepressants, or other drugs affecting gastric motility (or recorded and included as a covariate); 7. Severe renal insufficiency, active infection, cognitive failure to cooperate, unable to lie flat or unable to tolerate gastric ultrasound examination; 8. Severely abnormal thyroid function (significant hypothyroidism or hyperthyroidism) BMI >=35 kg/m² : 9. Pregnancy or breastfeeding; 10. Blood glucose > 16.7 mmol/L or < 3.9 mmol/L before drinking liquid and cannot be corrected in a short time
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The time interval from the completion of ingestion of 200 mL of clear fluid to the first confirmation of an empty stomach; | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in gastric content volume and antral CSA in the right lateral decubitus position at various time points;Aspiration-related complications;The incidence and severity of postoperative nausea and vomiting (PONV).; | — |
Countries
China
Contacts
Public ContactZhihua Wang
Hainan General Hospital
Outcome results
None listed