Postoperative depression and cognitive dysfunction in elderly patients
Conditions
Interventions
Es-ketamine group:During anesthesia induction, in addition to the routine use of anesthetic drugs, the observation group (Group E) was administered esketamine at a dose of 0.25 mg/kg
During the maintenance phase of anesthesia, esketamine is continuously administered via intravenous infusion at a rate of 0.125 mg/(kg·h), and the infusion is discontinued 20 minutes before the end of
Control group:During both anesthesia induction and maintenance, an equal volume of 0.9% normal saline was administered.
Sponsors
Yijishan Hospital, the First Affiliated Hospital of Wannan Medical College
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Scheduled for laparoscopic resection of gastrointestinal tumors; 2.Age >=65 years; 3.ASA classification I-III; 4.No cognitive impairment or mental disorders before the operation.
Exclusion criteria
Exclusion criteria: 1.Refusal to participate in the study; 2.Individuals with communication barriers; 3.Those allergic to esketamine or with contraindications for its use; 4.Patients with severe liver, kidney, lung, or cardiovascular diseases before surgery; 5.Severe acute infections.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Scores on the Hospital Anxiety and Depression Scale were obtained through follow - up assessments before surgery, 3 days after surgery, 1 week after surgery, and 1 month after surgery.;Pre - operatively, as well as at 3 days, 1 week, and 1 month post - operatively, the Mini - Mental State Examination (MMSE) was employed to assess the patients' cognitive function.;Cytokine:tumor necrosis factor a (TNFa), interleukin - 6 (IL - 6), and the related factor S100 calcium - binding protein ß (S100ß protein) were measured using the enzyme - linked immunosorbent assay (ELISA).; | — |
Secondary
| Measure | Time frame |
|---|---|
| Resting Visual Analog Scale (VAS) scores at 2, 6, 12, 24, and 48 hours post - operation;VAS scores during activities at 12 h, 24 h, and 48 h after surgery;The intraoperative dosages of propofol and sufentanil;Whether additional analgesic medications were administered within 48 hours after the surgery;At various time points, including the baseline (T0), intubation (T1), skin incision (T2), after pneumoperitoneum (T3), and 5 minutes after extubation (T4), the levels of mean arterial pressure (MAP) and heart rate (HR) were measured using a multi-parameter physiological monitor.;Instances of adverse reactions such as dizziness, nausea and vomiting, polyglot agitation, and nightmares; | — |
Countries
China
Contacts
Public ContactWei Chen;Yan Lu
Yijishan Hospital, the First Affiliated Hospital of Wannan Medical College
Outcome results
None listed