Alzheimers disease
Conditions
Interventions
Gamma Transcranial Alternating Current Stimulation (tACS) Group:Transcranial Alternating Current Stimulation (tACS)
Sponsors
Xuanwu Hospital Capital Medical University
Eligibility
Sex/Gender
All
Age
50 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1.Inpatients or outpatients aged 50–90 years; 2.Patients diagnosed with amnestic mild cognitive impairment (aMCI) due to AD or mild dementia due to AD, based on the 2018 NIA-AA clinical diagnostic criteria established by the National Institute on Aging and the Alzheimer’s Association; 3.Neuropsychological assessment showing MMSE scores between 18 and 26, and a CDR score of 0.5 or 1; 4.Able to communicate fluently in Chinese (non-illiterate); 5.For those currently receiving cholinesterase inhibitor therapy (e.g., donepezil or rivastigmine), the treatment dose must be stable, defined as a fixed dosage administered continuously for at least six weeks, with no adjustment of the medication regimen during the study period; 6.Provision of written informed consent. 7. Positive amyloid PET, or decreased amyloid levels in cerebrospinal fluid, or elevated serum phosphorylated Tau217 protein.
Exclusion criteria
Exclusion criteria: 1. Sudden onset of illness; 2. Early focal neurological symptoms or extrapyramidal symptoms; 3. Presence of systemic diseases that may lead to cognitive impairment (such as liver or kidney dysfunction, endocrine disorders, and vitamin deficiencies), or neurological diseases such as brain trauma, epilepsy, encephalitis, and normal pressure hydrocephalus; 4. Meets DSM-IV criteria for depression and schizophrenia; 5. Ongoing medication that may affect baseline and follow-up study periods; 6. Patients with contraindications to MRI and neurophysiological examinations, such as those with cardiac pacemakers, defibrillators, implanted electronic systems, vascular clips, mechanical heart valves, or cochlear implants; 7. Cranial MRI showing ischemic lesions consistent with NINCDS-AIREN criteria.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Moca score; | — |
Countries
China
Contacts
Public ContactYueyi Yu
Xuanwu Hospital, Capital Medical University
Outcome results
None listed