None
Conditions
Interventions
Fospropofol Disodium Group (Group P):Under wireless wearable (multi-parameter) real-time monitoring, elderly patients were given fospropofol disodium 12.5 mg/kg and sufentanil 0.1 µg/kg d
Propofol Group (Group C):Under wireless wearable (multi-parameter) real-time monitoring, elderly and middle-aged patients undergoing painless colonoscopy are given propofol 2.
Sponsors
Department of Anesthesiology, Chengdu Second People's Hospital
Eligibility
Sex/Gender
All
Age
50 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Patients aged 50 years and above undergoing sedated colonoscopy 2.The estimated procedure duration is 20 to 30 minutes. 3.No history of cognitive impairment or able to provide informed consent.
Exclusion criteria
Exclusion criteria: 1. Body mass index greater than 30 kg/m^2; 2. history of cerebral or thoracic/abdominal aortic aneurysm; 3. hypersensitivity to any of the drugs administered in the study; 4. Severe hepatic or renal impairment; 5. cardiovascular disease (history of heart failure, valvular disease, New York Heart Association Class III or IV) 6. cardiac arrhythmias (including but not limited to premature ventricular, atrial or atrial fibrillation, atrial flutter, etc.) 7. Use of antidepressants or antipsychotics; 8. mean arterial pressure (MAP) <70 mmHg before induction of anaesthesia; 9. oxygen saturation <92% without oxygen; 10. anticipated difficult airway; 11. ineligibility for inclusion as determined by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The composite endpoint of hypoxaemia, hypotension and bradycardia within 15 minutes of induction commencement; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of low heart rate;Incidence of hypoxaemia; | — |
Countries
China
Contacts
Public ContactJiang Rongjuan
Chengdu Second People's Hospital
Outcome results
None listed