Schizophrenia
Conditions
Interventions
cTBS + real stimulation:cTBS + real stimulation
Sham stimulation control group:Sham stimulation control (using the same coil with a shielding device to simulate sounds and sensations)
High-frequency rTMS (10Hz) + real stimulation:High-frequency rTMS (10Hz) + real stimulation
iTBS + real stimulation:iTBS + real stimulation
Sponsors
Jiangxi Mental Health Center
Eligibility
Sex/Gender
All
Age
18 Years to 55 Years
Inclusion criteria
Inclusion criteria: 1.Meet the DSM-5 diagnostic criteria for schizophrenia; 2.aged 18-55 years; 3.in clinical stable phase (no medication change for at least 3 months, PANSS total score < 75, Positive Symptoms Subscale score < 20); 4.with definite cognitive impairment (MCCB total score <= 1.5 SD below the norm or confirmed by baseline assessment); 5.right-handed; 6.able to understand the study content and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Have contraindications to rTMS (such as intracranial metal implants, history of epilepsy, severe heart disease, etc.); 2.suffer from severe physical diseases, neurological diseases, or substance abuse; 3.be pregnant or lactating women; 4.have received electroconvulsive therapy (ECT) or rTMS treatment in the past 6 months; 5.have intellectual disability.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Measurement and Treatment Research to Improve Cognition in Schizophrenia (MCCB) Score;Positive and Negative Syndrome Scale(PANSS) Score;Clinical Global Impression Scale (CGI) Score;Calgary Depression Scale for Schizophrenia (CDSS) Score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Insulin-like Growth Factor 2 (IGF-2); | — |
Countries
China
Contacts
Public ContactHu Wei
Jiangxi Mental Health Center
Outcome results
None listed