Hypertensive nephropathy
Conditions
Interventions
Non early hypertensive nephropathy group:None
Early stage hypertensive nephropathy group:None
Sponsors
Affiliated hangzhou first people's hospital, zhejiang university school of medicine
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Hypertensive patients: Inclusion criteria: 1.Age:Generally 18-75 years. 2. Diagnostic Criteria: Fulfilling the diagnosis of hypertension (systolic blood pressure >140 mmHg and/or diastolic blood pressure >=90 mmHg) with at least two measurements or on antihypertensive medication. 3. Disease duration: No definite limit, but a medical history is required. 4. Stable condition: no hypertensive crisis or serious complications. 5.No renal injury related disease 6.Voluntary participation in the study and signing the informed consent form. Patients with early hypertensive nephropathy/entry criteria: 1.Meet the diagnosis of hypertension. 2. Indicators of early renal impairment: microproteinuria (urine microalbumin/creatinine ratio >30 mg/g and =300 mg/g or overt proteinuria (>=0.3 g/24 hours). Or imaging and histological evidence suggesting structural renal damage. 3. Long history of hypertension (e.g. >10 years).
Exclusion criteria
Exclusion criteria: Patients with hypertension: 1. Combined with serious diseases of other organ systems (e.g., severe heart failure, liver failure, etc.) 2. Combination of serious infections or inflammatory diseases. 3. Well-pregnant or breastfeeding women. 4. Allergy to study drugs or test items. 5. Combination of malignant hypertension or secondary hypertension (e.g., renal artery stenosis, chromocytoma, etc.) Early stage hypertensive nephropathy patients. 1. Combination of other renal diseases with clear causes (e.g. diabetic nephropathy, chronic glomerulonephritis, drug-induced renal damage). 2. eGFR=300 mg/g). 3. Combination of severe cardiovascular and cerebrovascular diseases (e.g. acute coronary syndrome, stroke, etc.). 4. Combined infectious diseases or inflammatory states. 5. Other factors affecting the results of the study (e.g., poor medication adherence, recent history of surgery, etc.). Patients with non-early hypertensive nephropathy/ 1. Combined end-stage renal disease (ESRD, requiring long-term dialysis). 2. Clear secondary causes of kidney damage (e.g. lupus nephritis, multiple myeloma-related nephropathy). 3. Combination of severe hypertension that is difficult to control (e.g., requires a combination of 3 or more drugs and the blood pressure remains uncontrolled). 4. Combination of severe systemic diseases or recent acute events (e.g., heart attack, infection, etc.).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Renal spatial metabolomics;Urine Metabolomics; | — |
Countries
China
Contacts
Public ContactYongke Zheng
Affiliated hangzhou first people's hospital, zhejiang university school of medicine
Outcome results
None listed