Brain tumor
Conditions
Interventions
Lidocaine group:10 minutes before anesthesia induction, lidocaine 1.5mg/kg was intravenously injected. During the operation, lidocaine was continuously pumped at a rate of 1.0mg/kg per hour. The pumpi
Control group:10 minutes before anesthesia induction, 1.5 mg/kg of normal saline was intravenously injected in equal volume. During the operation, 1.0 mg/kg/h of normal saline was continuously pumped.
Sponsors
The Affiliated Hospital of Xuzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age >= 18 years old; 2. ASA classification: grade II or III; 3. BMI: 18 - 30 kg/m^2; 4. Elective craniotomy for tumor resection under general anesthesia, without any prior radiotherapy or chemotherapy; 5. Simple mental state score (MMSE) normal: illiterate >= 17, primary school education >= 20, secondary school or higher education >= 24; Montreal Cognitive Assessment (MoCA) normal: >= 26 points. For those with an education level of <= 12 years (high school or below), the original score is corrected by adding 1 point.
Exclusion criteria
Exclusion criteria: 1. Emergency surgery; 2. Preoperative cognitive dysfunction or history of neurological disorders; 3. BMI >= 30 kg/m^2 or underweight (< 40 kg); 4. Obvious sinus tachycardia (heart rate < 50 beats/minute) or other severe cardiovascular diseases; 5. Hypoproteinemia; 6. Long-term use of psychotropic drugs, alcohol abuse; 7. Severe liver and kidney dysfunction; 8. History of surgery in the last 3 months; 9. Unable to complete the scale of this study; 10. Allergic to the drugs involved in this study; 11. Already participated in other clinical studies.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative delirium; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mini Mental State Scale score;Numerical rating scale score , NRS;Cognitive function status 30 days after operation;Hospital anxiety depression anxiety subscale score;Neutrophil to lymphocyte ratio; | — |
Countries
China
Contacts
Public ContactXiuxia Chen
The Affiliated Hospital of Xuzhou Medical University
Outcome results
None listed