High-Altitude Polycythemia(HAPC)
Conditions
Interventions
Study 3: experimental group:Percutaneous Radiofrequency Renal Denervation
Study 3: Control Group:Conventional Hypertension Treatment
Study 1: Non-Invasive Ventilator Group:Treated with BIPAP or CPAP mode
Study 1: Control Group:Conventional Basic Treatment
Study 2: experimental group:The experimental group received inhaled nitric oxide treatment.
Study 2: control group:Regular oxygen inhalation therapy
Sponsors
Xizang Autonomous Region People's Hospital/Tibet High Altitude Medical Research Institute
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Clinical Efficacy Study of Non-Invasive Ventilator in the Treatment of High-Altitude Polycythemia: (1) Diagnosed with high-altitude polycythemia (HAPC); (2) Aged 18 years or older, with no gender restriction; (3) Voluntarily participate in the study and sign the informed consent form. 2.Clinical Efficacy Of Inhaled Nitric Oxide In High-Altitude Pulmonary Edema: (1) Diagnosed with high-altitude pulmonary edema; (2) Aged 18 years or older, with no gender restrictions; (3) Voluntarily participating in the study; (4) And signing an informed consent form. 3.Therapeutic Efficacy Evaluation of Radiofrequency-Based Renal Denervation in Patients with Resistant Hypertension or Poor-Adherence Hypertension in High-Altitude: (1) Meet the diagnostic criteria for hypertension. (2) Age >=18 years, with no gender restrictions. (3) Voluntarily participate in the study and provide written informed consent. (4) Hypertensive patients whose blood pressure remains uncontrolled (office blood pressure >=150/90 mmHg and 24-hour ambulatory systolic blood pressure (ASBP) >=135 mmHg) after one month of standardized treatment with two or more antihypertensive drugs.
Exclusion criteria
Exclusion criteria: 1.Clinical Efficacy Study of Non-Invasive Ventilator in the Treatment of High-Altitude Polycythemia: (1) Impaired consciousness; (2) Inability to spontaneously clear airway secretions, with a risk of aspiration; (3) Severe upper gastrointestinal bleeding; (4) Hemodynamic instability; (5) Upper airway obstruction; (6) Untreated pneumothorax or mediastinal emphysema; (7) Inability to wear a mask (e.g., facial trauma or deformity); (8) Patient non-compliance. 2.Clinical Efficacy Of Inhaled Nitric Oxide In High-Altitude Pulmonary Edema: (1) Diagnosed with nitric oxide allergy. (2) Refusal to participate in the experiment. 3.Therapeutic Efficacy Evaluation of Radiofrequency-Based Renal Denervation in Patients with Resistant Hypertension or Poor-Adherence Hypertension in High-Altitude: (1) Patients with unilateral or bilateral renal artery anatomy unsuitable for intervention (renal artery stenosis >50%, renal artery aneurysm, renal artery malformation, fibromuscular dysplasia) ; renal transplant recipients; estimated glomerular filtration rate (eGFR) <45 mL/(min·1.73 m²) ; (2) History of cardiovascular events (stable/unstable angina, myocardial infarction) or cerebrovascular events (stroke, cerebrovascular accident, transient ischemic attack) within the preceding 6 months ; (3) Age <18 years
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood Routine Test;Liver Function;renal function;C-reactive protein;Electrocardiogram(ECG);Echocardiogram(Echo);Polysomnography(PSG);Chest CT scan;oxygen saturation(SPO2);blood gas analysis;Ambulatory Blood Pressure Monitoring (ABPM); | — |
Countries
China
Contacts
Public ContactKelsang Norbu
Xizang Autonomous Region People's Hospital
Outcome results
None listed