Non-suicidal self-injury
Conditions
Interventions
Sponsors
Guangji Hospital
Eligibility
Sex/Gender
All
Age
12 Years to 18 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria for the NSSI with high/low impulsivity group: 1. Meet the diagnostic criteria for NSSI in the Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5): the presence of non-fatal self-injurious behaviours (excluding behaviours with clear suicidal intent), such as cutting or stabbing the skin with sharp objects, making wounds in the same area, especially in places that are easily hidden but easily accessible (e.g., forearms, front of thighs), burning the skin, and so on. Cutting or stabbing the skin with sharp objects, burning the skin, etc., and making multiple wounds in the same area, especially in easily concealed but accessible areas (e.g., forearms, front of thighs); 2. Age 12-18 years old; 3. the patients themselves and their guardians were aware of the study and volunteered to participate in the study; 4. maintain the same type and dose of SSRI antidepressant medication continuously for at least 15 days prior to enrolment and throughout the treatment period; 5. be divided into high impulsivity and low impulsivity groups (above average and below average scores, respectively) on the basis of the UPPS-P scale scores (the mean of the total scores is the cut-off). Inclusion criteria for normal control group: 1. no complaints of cognitive impairment; 2. normal neurological examination; 3. normal core cognitive scales; 4. multidimensional cognitive neuropsychological assessment scale within the normal range of age and education matched.
Exclusion criteria
Exclusion criteria: Exclusion criteria: 1. history of impaired consciousness; 2. family history of hereditary diseases; 3. somatic diseases such as central nervous system infections, head injuries, epilepsy, multiple sclerosis, toxic metabolic disorders, intracranial tumours, hypothyroidism, diabetes mellitus; 4. a history of psychiatric disorders such as schizophrenia, manic episodes, bipolar disorder, personality changes, etc; 5. high suicide risk groups with a recent or long-term history of clear suicidal ideation, suicide plan, suicide attempt, or with severe mental disorders and psychosocial risk factors related to suicide; 6. Combined serious heart, liver, kidney, brain and haematopoietic system diseases; 7. Contraindications to MRI scanning such as implantation of electronic and metal devices; 8. History of electroconvulsive therapy in the last 3 months; 9. T2-weighted MRI showing cerebral white matter damage.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Self-harm Frequency and Severity Score;Degree of depression;Cognition;Sleep quality; | — |
Countries
China
Contacts
Public ContactTian Qing
GuangJi Hospital
Outcome results
None listed