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Study on the mechanism and targeted intervention of protein lactylation mediating sepsis-associated ICU-acquired weakness through epigenetic regulation of the ferroptosis pathway

Study on the mechanism and targeted intervention of protein lactylation mediating sepsis-associated ICU-acquired weakness through epigenetic regulation of the ferroptosis pathway

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600117954
Enrollment
Unknown
Registered
2026-01-30
Start date
2026-02-01
Completion date
Unknown
Last updated
2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sepsis, ICU-acquired weakness

Interventions

MRC >=48 points were used as the control group (sepsis without ICU-AW):N/A

Sponsors

Zhejiang Provincial People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1.Adult patients meeting the Sepsis-3.0 diagnostic criteria (acute increase in SOFA score >=2 points);

Exclusion criteria

Exclusion criteria: 1.Pre-existing neuromuscular disease; 2.muscle weakness present before ICU admission; 3.cranial injury; 4.spinal cord injury; 5.pregnancy; 6.expected ICU stay <48 hours;

Design outcomes

Primary

MeasureTime frame
Blood lactate;Iron death index;Lactylation level;—

Countries

China

Contacts

Public ContactLulu Lou

Zhejiang Provincial People's Hospital

814620085@qq.com+86 571 87312785

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 7, 2026