New-Onset Atrial Fibrillation (NOAF)
Conditions
Interventions
Sepsis non-NOAF group:No
Sepsis NOAF group:NO
Sponsors
Fuzhou University Affiliated Provincial Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Met the Sepsis-3 diagnostic criteria (infection with Sequential Organ Failure Assessment [SOFA] score >=2); 2. New-onset atrial fibrillation occurring after ICU admission, confirmed by nursing records or electrocardiogram (ECG); 3. Aged 18–80 years; 4. Survived without self-discharge within 48 hours of ICU admission.
Exclusion criteria
Exclusion criteria: 1. History of paroxysmal or persistent atrial fibrillation prior to ICU admission; 2. Prior cardiac surgery (valve replacement, coronary artery bypass grafting), myocarditis, dilated cardiomyopathy, hypertrophic cardiomyopathy, rheumatic heart disease, or congenital heart disease; 3. Malignant tumor, organ transplant, or autoimmune disease; 4. Hyperthyroidism or pheochromocytoma; 5. Immunosuppressive therapy, hormone therapy, or immune checkpoint inhibitors within the preceding six months; 6. Pregnancy; 7. Human immunodeficiency virus (HIV) infection; 8. Chronic renal failure requiring hemodialysis or peritoneal dialysis; 9. Multiple ICU admissions (only the first ICU stay was retained.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Complete Blood Count;Liver and kidney function tests, Electrolytes ;NT-proBNP and troponin I;Procalcitonin (PCT), C-reactive protein, IL-6;Lipid profile;Incidence, recurrence, and cardioversion of atrial fibrillation;ICU mortality, in-hospital mortality, and mortality at 28, 60, 90, and 180 days;Lactate and blood gas Blood gas analysis; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hospital LOS (Length of Stay), ICU LOS ; | — |
Countries
China
Contacts
Public ContactCuilian Weng
Fuzhou University Affiliated Provincial Hospital
Outcome results
None listed