Sepsis
Conditions
Interventions
Healthy control group:None
Sponsors
Zhejiang Provincial People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1.All patients should be aged 18–70 years; 2.Meet the diagnostic criteria for sepsis, with a Sepsis-related Organ Failure Assessment (SOFA) score of 2 or higher, and have a clearly identified source of infection; 3.First-time diagnosis of sepsis, with no prior immunosuppressive therapy; 4.All patients or their family members should have provided signed informed consent.
Exclusion criteria
Exclusion criteria: 1.Patients with severe immunodeficiency diseases, such as HIV infection or advanced malignant tumors; 2.Pregnant or lactating women; 3.Having received immunomodulatory therapy, such as anti-PD-1 antibody, within 72 hours prior to enrollment; 4.Severe hepatic or renal insufficiency (e.g., baseline creatinine >200 µmol/L or ALT >3 times the upper limit of normal [ULN]); 5.Life expectancy of less than 7 days (e.g., due to severe multiple organ failure).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Lymphocyte activation gene-3,CD8+ Tcell(LAG3+ CD8+ Tcell)?Fibrinogen-like protein 1(FGL1); | — |
Countries
China
Contacts
Public ContactJuanjuan Li
Zhejiang Provincial People's Hospital
Outcome results
None listed