Intracranial aneurysm
Conditions
Interventions
aSAH:None
Health group:None
Sponsors
Tianjin Medical University General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Age: 18 to 70 years old (inclusive), any gender. 2. Diagnosis: First-ever acute aneurysmal subarachnoid hemorrhage (aSAH) confirmed by cranial CT or lumbar puncture. 3. Aneurysm Management: The aneurysm has been successfully treated by endovascular intervention or microsurgery, with satisfactory aneurysm occlusion confirmed by postoperative digital subtraction angiography (DSA) or computed tomography angiography (CTA). 4. Time from Onset: The interval from hemorrhage onset to signing the informed consent form is within 72 hours. 5. Informed Consent: The patient or their legal representative understands the study procedures and voluntarily signs the written informed consent form.
Exclusion criteria
Exclusion criteria: 1.Non-aneurysmal SAH: Subarachnoid hemorrhage caused by arteriovenous malformations, trauma, brain tumors, Moyamoya disease, or other non-aneurysmal etiologies. 2. Significant pre-existing medical history: Pre-existing dementia or cognitive impairment prior to hemorrhage (e.g., Alzheimer’s disease, vascular dementia). History of other major neurological disorders (e.g., brain tumor, severe traumatic brain injury, encephalitis, epilepsy, Parkinson’s disease). History of severe psychiatric disorders (e.g., schizophrenia, major depression). 3. Physical conditions affecting assessment: Severe cardiac, hepatic, or renal dysfunction, or any other serious systemic disease with life expectancy less than one year. Sensory impairments (e.g., severe visual or hearing loss) or motor impairments preventing completion of neuropsychological assessments. 4. Imaging contraindications: Presence of non-MRI-compatible implants (e.g., pacemakers, certain types of aneurysm clips) or severe claustrophobia preventing 3.0T MRI scanning. 5. Contraindications to invasive procedures: 1) Severe coagulation disorders or local infection at lumbar puncture site preventing CSF collection. 2)Other conditions: Pregnant or breastfeeding women. 3)Any other condition deemed by the investigator as unsuitable for participation (e.g., poor compliance, inability to complete follow-up). 6.Study Discontinuation and Withdrawal Criteria 1)Occurrence of serious adverse events making continued participation inappropriate, as judged by the investigator. 2)Withdrawal requested by the participant or their legal representative during the study. 3)Loss to follow-up. 4)Investigator determines that the participant does not meet the inclusion criteria or meets any exclusion criteria (i.e., ineligible enrollment). 5)Major protocol amendments rendering the study unsuitable for the participant to continue.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Montreal Cognitive Assessment (MoCA);Mini-Mental State Examination (MMSE);Diffusion Tensor Imaging–Analysis Along the Perivascular Space (DTI/ALPS);Brain Network Assessment; | — |
Countries
China
Contacts
Public ContactXinyu Yang
Tianjin Medical University General Hospital
Outcome results
None listed