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The effect of hydrogen-oxygen inhalation on the dosage of morphine after artificial joint replacement surgery

The effect of hydrogen-oxygen inhalation on the dosage of morphine after artificial joint replacement surgery

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2600117907
Enrollment
Unknown
Registered
2026-01-29
Start date
2025-12-08
Completion date
Unknown
Last updated
2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteoarthritis/Femoral head necrosis

Interventions

Conventional treatment control group:Postoperative analgesia with morphine is administered. When pain control is unsatisfactory, tramadol injection for supplementary analgesia and oxygen inhalation ar
Hydrogen inhalation therapy group:On the basis of postoperative analgesia, hydrogen-oxygen mixed inhalation was given at a flow rate of 3L/min for 6 hours

Sponsors

The Affiliated Tai’an City Central Hospital of Qingdao University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
40 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1.The diagnoses of femoral head necrosis, osteoarthritis, femoral head fractures, etc. are clear. 2. Age: 40 to 80 years old, with symptoms of chronic diseases such as hypertension and diabetes well controlled. 3. Good compliance and cooperation in clinical research.

Exclusion criteria

Exclusion criteria: 1.Patients with neuropathic pain who are currently using or are considered by their doctors to need anticonvulsant or antidepressant drugs (such as those with tumors compressing the nerve trunk, plexus, or spinal cord); 2. Analgesic drugs other than those under study, including NSAIDs, are currently in use or are considered necessary by a doctor. 3. There are unstable concomitant diseases; Or patients with functional disorders of important organs; 4. Unable to cooperate with patients who have poor compliance.

Design outcomes

Primary

MeasureTime frame
Morphin consumption;Superoxide dismutase;

Secondary

MeasureTime frame
Cytokine(IL-6TNF-aIL-b);C-reactive protein;Pain score;

Countries

China

Contacts

Public ContactWu Xue

The Affiliated Tai’an City Central Hospital of Qingdao University

tazxwx@163.com+86 182 6538 4195

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 7, 2026