cardiogenic shock
Conditions
Interventions
treatment group:The patient was administered remifentanil (4 units of 50 ml, with a concentration of 0.08 mg/ml). The initial bolus injection was 1 ug/kg, with a injection speed of more than 1 minute.
control group:The fentanyl group received a loading dose of 0.35 µg/kg (lasting for more than 1 minute), followed by a continuous infusion at 0.7 µg/kg/h, with a maximum infusion rate of 10 µg/kg/h. T
Sponsors
The first hospital of jilin university
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age 18–80 years; 2. 2019 SCAI cardiogenic shock stage C, D or E (judged by two researchers, with the disagreement resolved by PI); 3. Mechanical ventilation has been initiated, and randomization can be completed within = 5 points (based on the complete score within <= 2 hours before randomization); 5. Screening and randomization were completed within <= 6 hours from the first definite SCAI C/D/E diagnosis or the first administration of vasoactive drugs (whichever occurred earlier); 6. Obtained consent from the patient or legal representative; Delayed consent can be enabled in emergency situations, with supplementary signing within 48 hours.
Exclusion criteria
Exclusion criteria: 1. History of allergy to remifentanil, fentanyl or related drugs; 2. Mental disorders (such as inability to cooperate with the study), chronic pain, epilepsy, severe brain diseases leading to increased ICP; 3. Severe coma (GCS <= 5 points and no need for sedation/analgesia support); 4. Severe liver or kidney dysfunction (such as eGFR < 30 ml/min/1.73m², Child-Pugh C grade); 5. Patients with terminal malignant tumors, pregnant or lactating women, or those who cannot undergo long-term follow-up due to terminal conditions; 6. Participated in other drug clinical trials in the past 1 month.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 24-hour lactate clearance rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| 72-hour hemodynamic stability composite endpoint;Core hemodynamic parameters;Cardiac function indicators;Cardiac troponin ;6-hour lactate clearance rate;Duration of mechanical ventilation;Length of stay in CCU;Adverse event occurred; | — |
Countries
China
Contacts
Public ContactYushi Wang
The First Hospital of Jilin University
Outcome results
None listed