Crohn's disease (CD)
Conditions
Interventions
CD patients with hypertrophic small bowel strictures requiring surgical treatment:none
CD patients with stricturing small bowel stenosis requiring surgical treatment:none
Sponsors
Wuxi people’s Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Age between 18 and 65 years; 2.Diagnosed with Crohn’s disease (CD) based on the diagnostic criteria outlined in the Chinese Consensus Guidelines for the Diagnosis and Treatment of Crohn’s Disease (2023, Guangzhou), through comprehensive analysis of clinical presentation, laboratory tests, imaging, endoscopic findings, and histopathological features, after excluding infectious and other non-infectious forms of colitis; 3.Presence of small bowel stricture confirmed by clinical presentation, imaging findings, and in accordance with the European Crohn’s and Colitis Organisation (ECCO) guidelines; 4.Indication for surgery according to the 2020 Expert Consensus on Surgical Treatment of Inflammatory Bowel Disease; 5.Scheduled for surgical treatment with availability of intact lesion tissue; the patient has signed an informed consent form.
Exclusion criteria
Exclusion criteria: 1.Confirmed concurrent active infection (e.g., tuberculosis, CMV, etc.); 2.Concurrent malignancy or other autoimmune diseases; 3.Presence of other severe comorbidities or inability to complete follow-up; 4.Pregnant or lactating women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Complete Blood Count, liver and kidney function, Erythrocyte Sedimentation Rate [ESR], C-Reactive Protein [CRP]/high-sensitivity CRP [hsCRP];Imaging features: CT, MRI, intestinal ultrasound;Transcriptome?Whole Genome??Epigenome ?Proteome?Metabolome ?Spatial Transcriptomics;Other Montreal Classification Indicators (Stricture Location, Disease Behavior, Perianal Involvement); | — |
Secondary
| Measure | Time frame |
|---|---|
| Demographic Characteristics;CDAI Score; | — |
Countries
China
Contacts
Public ContactSun Jing
Wuxi people’s Hospital
Outcome results
None listed