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A Cohort Study on the Effects of a Graded Intervention Strategy Based on Injury Severity Classification on the Progression of Acute Ankle Sprains to Chronic Ankle Instability and Functional Outcomes

A Cohort Study on the Effects of a Graded Intervention Strategy Based on Injury Severity Classification on the Progression of Acute Ankle Sprains to Chronic Ankle Instability and Functional Outcomes

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600117893
Enrollment
Unknown
Registered
2026-01-29
Start date
2026-01-30
Completion date
Unknown
Last updated
2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ankle sprain

Interventions

Standardized Intervention Group:None
Non-standard intervention group:None

Sponsors

Rehabilitation Medicine Center, The First Affiliated Hospital of Nanjing Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: 1. Age 18–60 years old; 2. Meet the clinical diagnosis of acute ankle sprain; 3. Injury occurred within 3 weeks and no professional rehabilitation training has been received; 4. Eligible participants can sign the informed consent form themselves, voluntarily participate, and commit to completing follow-up.

Exclusion criteria

Exclusion criteria: 1. History of ankle surgery or trauma; 2. Suffering from neurological diseases, rheumatoid arthritis, diabetes, or other conditions that may affect lower limb movement; 3. History of deep vein thrombosis or other circulatory disorders; 4. Participation in other studies that may affect ankle joint function; 5. Individuals with deafness, severe speech disorders, or other conditions preventing cooperation with examinations; 6. Presence of metal implants or other contraindications for MRI.

Design outcomes

Primary

MeasureTime frame
The incidence of chronic ankle instabilityThe incidence ofThe incidence of chronic ankle instability chronic ankle instability;

Secondary

MeasureTime frame
Y-Banlance Test;Proprioception Test;Muscle Strength Test;Visual Analogue Scale (VAS) Pain Score;Transcranial Magnetic Stimulation;H reflex;Three-Dimensional Gait Analysis;Functional Magnetic Resonance Imaging;

Countries

China

Contacts

Public ContactZhu Yi

Jiangsu Province Hospital, The First Affiliated Hospital of Nanjing Medical University

ZhuYi1981@njmu.edu.cn+86 137 0516 4030

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 7, 2026