Thyroidectomy with Intraoperative Recurrent Laryngeal Nerve Monitoring Under General Anesthesia
Conditions
Interventions
Control group:5% glucose injection, intravenous infusion: Loading volume 0.4ml/kg (10 minutes before anesthesia induction), maintenance volume 0.2ml/kg/h (until the end of the operation)
Trial group:Dilute 50% magnesium sulfate injection to 10% concentration for intravenous infusion: loading volume 0.4ml/kg (10 minutes before anesthesia induction), maintenance volume 0.2ml/kg/h (until
Sponsors
Fifth Affiliated Hospital, Sun Yat-Sen University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1.Voluntarily signed informed consent form; 2.Aged between 18 and 60 years; 3.No gender restriction; 4.ASA physical status classification I-II; 5.Patients undergoing thyroidectomy with intraoperative recurrent laryngeal nerve monitoring under general anesthesia.
Exclusion criteria
Exclusion criteria: 1.Preoperative systolic blood pressure 180 mmHg or diastolic blood pressure >90 mmHg; 3.Renal dysfunction (glomerular filtration rate [GFR] 97 µmol/L, blood urea nitrogen [BUN] >8 mmol/L); 4.History of neuromuscular disorders; 5.History of cardiac ischemia or conduction block; 6.Pregnancy or lactation; 7.Chronic calcium channel blocker therapy; 8.History of hypersensitivity to magnesium compounds or general anesthetic agents; 9.Electrolyte abnormalities (hypokalemia, hypocalcemia, hypermagnesemia); 10.Random blood glucose >11.1 mmol/L; 11.Body mass index (BMI) 30 kg/m²; 12.Anticipated difficult mask ventilation or intubation (limited mouth opening, restricted head/neck mobility, short thyromental distance, or history of difficult intubation).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The duration of action of muscle relaxants; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of adverse events;The incidence of glottic activity, diaphragmatic movement and choking cough during tracheal intubation; | — |
Countries
China
Contacts
Public ContactYang Simin
Fifth Affiliated Hospital, Sun Yat-Sen University
Outcome results
None listed