Childhood glaucoma
Conditions
Interventions
Trab group :Trabeculectomy surgery
Tube group :Tube shunt surgery
Sponsors
Beijing Tongren Hospital
Eligibility
Sex/Gender
All
Age
No minimum to 17 Years
Inclusion criteria
Inclusion criteria: I. Inclusion Criteria for Childhood Glaucoma / II. Inclusion Criteria for Glaucoma Following Cataract Surgery in Children: 1.Compliance with Diagnostic Criteria for Childhood Glaucoma: Age: 0–17 years old. Diagnosis: Must meet at least two of the following criteria: Intraocular Pressure (IOP): >21mmHg. Optic Disc Changes: Enlargement or cupping (neuroretinal rim thinning). In cases of similar optic disc size, a cup-to-disc (C/D) ratio asymmetry >= 0.2, focal rim thinning, or progressive C/D ratio enlargement (diffuse rim thinning). Corneal Changes: Presence of Haab striae, corneal edema, or enlarged corneal diameter >= 11 mm; infants 12mm; children of any age >13 mm). Axial Growth: Progressive myopia or myopic shift associated with an axial length increase exceeding normal physiological growth rates. Visual Field Defects: Reproducible visual field defects corresponding to glaucomatous optic neuropathy (after excluding other pathologies). 2.Follow-up/History Requirements: For General Childhood Glaucoma: At least one follow-up record is required (minimum 6 months post-surgery). For Post-Cataract Glaucoma: History of prior cataract surgery. 3.Consent & Compliance: Informed consent obtained from the patient and/or legal guardian, with demonstrated good compliance. III. Inclusion Criteria for Anterior Segment Dysgenesis (including Aniridia, Axenfeld-Rieger Syndrome, and Primary Congenital Glaucoma): 1.Diagnosis of Primary Congenital Glaucoma (PCG): Onset Age: = 21 mmHg prior to treatment. Clinical Symptoms: Presentation of one or more of the following: corneal edema, Haab striae, enlarged corneal diameter, C/D ratio >0.3 or asymmetry >0.2, and increased axial length. Exclusion of Anomalies: Absence of concurrent ocular or systemic developmental anomalies. Differential Diagnosis: Exclusion of any other potential causes for the above clinical changes. 2.Diagnosis of Axenfeld- Rieger Syndrome (ARS): Corneal Dysgenesis: Presence of posterior embryotoxon. Iris Dysgenesis: Abnormal iris development (e.g., corectopia, atrophy). Angle and Ocular Abnormalities: Developmental defects of the anterior chamber angle and other ocular tissues. Systemic Abnormalities: Developmental defects of the teeth and craniofacial bones, such as hypodontia, dental defects, abnormal tooth morphology, impacted teeth, or micrognathia. 3.Other ASD Conditions: Includes congenital aniridia and other anterior segment dysgenesis disorders.
Exclusion criteria
Exclusion criteria: I. Exclusion Criteria for Childhood Glaucoma: Non-glaucomatous Ocular Abnormalities: Presence of concurrent ocular conditions (unrelated to glaucoma) that significantly affect visual acuity, such as intraocular tumors or a history of corneal transplantation. Insufficient Follow-up: Patients with a postoperative follow-up duration of less than six months. Incomplete Surgical History: Patients for whom detailed information regarding prior surgical procedures is unavailable. II. Exclusion Criteria for Glaucoma Following Cataract Surgery in Children: Non-glaucomatous Ocular Abnormalities: Presence of concurrent ocular conditions (unrelated to glaucoma) that significantly affect visual acuity, such as intraocular tumors or a history of corneal transplantation. Incomplete Surgical History: Patients for whom detailed information regarding prior surgical procedures is unavailable. III. Exclusion Criteria for Primary Congenital Glaucoma, Axenfeld-Rieger Syndrome, and Aniridia: Secondary Glaucoma: Exclusion of all types of secondary glaucoma (except for those inherent to the specified syndromes). Non-glaucomatous Ocular Abnormalities: Presence of other ocular conditions that impair vision, such as ocular trauma or intraocular masses/tumors.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intraocular pressure;Types of anti glaucoma drugs; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of complications;Best corrected visual acuity;Visual acuity; | — |
Countries
China
Contacts
Public ContactQiao Chunyan
Beijing Tongren Hospital
Outcome results
None listed