The elderly patients are prone to hypotension and arrhythmia during anesthesia induction
Conditions
Interventions
P Group:Fospropfol
Sponsors
Sanbo Brain Hospital Capital Medical University
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >=60 years old, gender is not limited; 2.American Society of Anesthesiologists (ASA) : Level I-II; 3.Body mass index (BMI) : 18.5-28 kg/m^2; 4. Elective surgery is required under general anesthesia, and the estimated operation time is greater than 30 minutes; 5.Voluntary participation and signing of the informed consent form;
Exclusion criteria
Exclusion criteria: 1. Those who have contraindications to general anesthesia or have a history of anesthesia accidents; 2. Respiratory insufficiency, obstructive pulmonary disease, presence of a difficult airway, or determination of tracheal intubation difficulty (modified Markov score level III or IV); 3. uncontrolled diabetes or high blood pressure; 4.A history of drug use, alcoholism or drug dependence; 5. Abuse or long-term use of narcotic, sedative and analgesic drugs; 6.Those who are known or suspected to be allergic to or contraindicated by the process administration of various components or protocols of the study drug (sufentanil citrate injection, propofol medium/long chain fat milk, remifentanil hydrochloride for injection, and propofol disodium for injection); 7.People with a history of mental illness; 8. Participants in any drug clinical trial within 1 month before screening; 9. Subjects who have any other factors deemed unsuitable for participation in this study by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of hypotension during anesthesia induction; | — |
Secondary
| Measure | Time frame |
|---|---|
| Complications during the induction period of anesthesia;Total intraoperative dose of remifentanil;Use of vasoactive drugs during surgery;Serum alkaline phosphatase levels before and after surgery; | — |
Countries
China
Contacts
Public ContactYongxing Sun
Sanbo Brain Hospital Capital Medical University
Outcome results
None listed