Sepsis and its associated coagulopathy (SIC), accompanied by dysregulated inflammation, increased oxidative stress, and organ dysfunction.
Conditions
Interventions
Sepsis without coagulation dysfunction group:no
Healthy control group:None
Sepsis-Induced Coagulopathy Group:None
Sponsors
Taizhou Hospital of Zhejiang Province
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Sepsis group: age >=18 years, meeting the Sepsis-3 diagnostic criteria, and signing the informed consent form within 24 hours of admission; 2.Healthy control group: age- and sex-matched, without infectious diseases, coagulation disorders, or severe systemic illnesses.
Exclusion criteria
Exclusion criteria: 1.Age <18 years; 2.pregnant or breastfeeding women; 3.patients with malignant tumors, immune system diseases, or severe hepatic or renal dysfunction; 4.recent use of anticoagulants or immunosuppressants; 5.refusal to provide informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 28-day all-cause mortality; | — |
Secondary
| Measure | Time frame |
|---|---|
| Inflammatory cytokines (TNF-a, IL-6);Plasma PICK1 concentration;Oxidative stress markers (MDA, SOD);DIC score;Coagulation parameters (APTT, PT, D-dimer);SOFA score; | — |
Countries
China
Contacts
Public ContactYulong Yu
Taizhou Hospital of Zhejiang Province
Outcome results
None listed