Globus pharyngeus
Conditions
Sponsors
Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Age 18-75 years, gender-neutral; 2. Meeting the diagnostic criteria of Rome IV GP, i.e., persistent or intermittent non-painful throat choking sensation or foreign body sensation; absence of evidence of gastroesophageal reflux or eosinophilic esophagitis causing the symptoms; absence of major esophageal motility disorders; no structural lesions detected by physical examination, laryngoscopy, or endoscopy; symptoms persisting for >=6 months, meeting the above diagnostic criteria for the past 3 months, with symptom frequency of at least 1 day per week. 3. Total LUMP score >=6 points; 4. Voluntary acceptance of taVNS treatment and related assessments, with signed informed consent form.
Exclusion criteria
Exclusion criteria: 1. Recent (within 3 months) history of throat surgery or radiotherapy/chemotherapy; 2. Severe arrhythmias, heart failure, pacemaker implantation, or other conditions unsuitable for vagus nerve stimulation; 3. Severe mental disorders (e.g., major depressive disorder, schizophrenia) or recent suicidal ideation; 4. Pregnancy or lactation; 5. Severe hypersensitivity to electrical stimulation or auricular skin; 6. Inability to cooperate with follow-up or related examinations; 7. Other circumstances deemed unsuitable by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The Laryngopharyngeal Measure of Perceived Sensation;Heart Rate Variability; | — |
Secondary
| Measure | Time frame |
|---|---|
| Self-Rating Anxiety Scale;Self-Rating Depression Scale;Pittsburgh Sleep Quality Index;Inflammatory markers;Cytokine;Resting-state functional magnetic resonance imaging; | — |
Countries
China
Contacts
Public ContactXiaoyun Qian
Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University
Outcome results
None listed