Postoperative cognitive dysfunction
Conditions
Interventions
Experimental group (medication adjustment group using EEG and cerebral oxygen saturation monitoring).:The depth of sedation and analgesia was monitored using the HXD-I deep anesthesia monitoring instr
Control group (medication management group based solely on the anesthesia physician's experience, without adjusting according to EEG and cerebral oxygen saturation monitoring).:The medication was not
Sponsors
The Affiliated Sheng Jing Hospital of China Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Patients undergoing elective bowel resection surgery under general anesthesia at Shengjing Hospital of China Medical University from March 2025 to March 2026. 2.Patients with a preoperative Groningen Frailty Index (GFI) score of >=3, indicating frailty. 3.ASA classification: Class II-III. 4.Patients who voluntarily participate and sign informed consent after fully understanding the purpose, procedures, risks, and benefits of this study and discussing them with others.
Exclusion criteria
Exclusion criteria: 1. It was diagnosed as having cognitive impairment before the surgery. 2. It is expected that the patient will not be able to continue the treatment after the surgery. 3. The total hospital stay is less than three days. 4. Before the surgery, the patient had hearing or vision impairments, restricted use of the dominant hand, etc. (unable to complete the screening scale). 5. In the past 1 month, the patient has used drugs that may affect cognitive function or anesthesia effect (such as antidepressants, sedative-hypnotics, etc.). 6. The patient has a history of mental illness (such as depression, anxiety disorder, etc.). 7. The patient or the patient's family refuses to participate in the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of cognitive dysfunction on postoperative day 1 (D1) and postoperative day 3 (D2) in both groups.; | — |
Secondary
| Measure | Time frame |
|---|---|
| The incidence of cognitive dysfunction at postoperative 2 weeks and postoperative 1 month.;Richmond Agitation-Sedation Scale (RASS);Cerebral oxygen saturation (rSO2);Nine-Hole Peg Test scores before and after surgery;Postoperative hospital stay (days);Wavelet Index (WLi);Intraoperative medication dosage;The incidence of other anesthesia-related complications postoperatively (such as severe nausea and vomiting, dizziness, headache, etc.);Pain Threshold Index (PTi); | — |
Countries
China
Contacts
Public ContactBo Long
The Affiliated Sheng Jing Hospital of China Medical University
Outcome results
None listed