Postoperative pain after lumbar spine surgery
Conditions
Interventions
Bupivacaine Liposome Local Infiltration Group:Periwound local infiltration anesthesia with bupivacaine liposome
Bupivacaine Liposome ESPB Group:Ultrasound-guided bilateral erector spinae plane block was administered to the ESPB group prior to general anesthesia induction
Sponsors
Shaanxi 215 Hospital of nuclear industry
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Patients between 18 and 80 years of age; 2.Patients scheduled for posterior lumbar spine surgery (1-3 levels); 3.ASA grades 1-3; 4.BMI of 18.0 to 29.9 kg/m^²; 5.Informed consent was obtained from all patients or their legal representatives;
Exclusion criteria
Exclusion criteria: 1.Allergy to bupivacaine or any component of the liposomal formulation; 2.Pre-existing spinal cord injury; 3.Congenital spinal deformity; 4.Concomitant malignant tumor; 5.Severe systemic diseases, such as cardiopulmonary insufficiency, hepatic or renal dysfunction; 6.Chronic preoperative use of opioids or other analgesics leading to drug tolerance; 7.Coagulopathy or local infection at the potential puncture site(s); 8.Psychiatric disorders or cognitive impairment that would preclude cooperation with the study procedures; 9.Refusal to use a postoperative intravenous patient-controlled analgesia (PCA) pump; 10.Pregnancy or lactation;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative 72-hour opioid consumption; | — |
Secondary
| Measure | Time frame |
|---|---|
| Satisfaction with postoperative analgesia;Time to first ambulation and ambulation distance;The incidence of complications within 72 hours postoperatively, such as respiratory depression, nausea and vomiting, dizziness, and somnolence.;Consumption of rescue analgesics and time to first rescue analgesia;Intraoperative consumption of anesthetic agents;Pittsburgh Sleep Quality Index (PSQI) score;Static and dynamic NRS scores and NRS-AUC within the first 72 postoperative hours;Chronic pain;Length of hospital stay;Time to return of bowel function; | — |
Countries
China
Contacts
Public ContactLiuqin Jiang
Shaanxi 215 Hospital of nuclear industry
Outcome results
None listed