Metabolic Syndrome (MetS)
Conditions
Interventions
Observation Group:None
Control Group:None
Sponsors
China-Japan Union Hospital of Jilin University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Aged 18-65 years, regardless of gender; 2.Meeting the WHO diagnostic criteria for obesity: BMI >= 35 kg/m^2, or BMI >= 32.5 kg/m^2 with at least one comorbid metabolic complication (e.g., type 2 diabetes, hypertension, dyslipidemia, obstructive sleep apnea); 3.Deemed eligible for and planning to undergo either SADI-S or SG surgery, as assessed by the hospital's multidisciplinary team (MDT); 4.Undergoing bariatric surgery for the first time, with no history of prior bariatric/metabolic surgery; 5.Voluntarily agreeing to participate in the study, providing written informed consent, and committing to complete the 12-month postoperative follow-up.
Exclusion criteria
Exclusion criteria: 1.Use of antibiotics, probiotics, or agents affecting bile acid metabolism (e.g., cholestyramine) within the past 3 months; 2.Use of glucose-lowering medications that may significantly influence metabolism (e.g., GLP-1 receptor agonists, SGLT2 inhibitors) within the past 1 month; 3.Diagnosis of inflammatory bowel disease (e.g., Crohn's disease, ulcerative colitis) or active gastrointestinal malignancy; 4.History of major psychiatric disorders (e.g., depression, eating disorders) or substance abuse; 5.Current pregnancy or breastfeeding; 6.Any other condition that, in the investigator's judgment, would render the participant unsuitable for the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Percent Total Weight Loss (%TWL) at 12 Months Postoperatively;Changes in the relative abundance of specific bacterial genera (including Clostridium) in the fecal microbiome;Changes in the plasma concentrations of secondary bile acids; | — |
Secondary
| Measure | Time frame |
|---|---|
| Weight;Fasting blood sugar;Glycated hemoglobin;Insulin resistance index; | — |
Countries
China
Contacts
Public ContactTao Jiang
China-Japan Union Hospital of Jilin University
Outcome results
None listed