Chronic cerebral hypoperfusion (CCH)
Conditions
Interventions
Gamma-tTIS intervention group (self-control):Hippocampus-targeted 40-Hz Gamma-tTIS: dual-channel carriers at 2000/2040 Hz generating a 40-Hz envelope
total injected current 2.0 mA
20 min/session
once daily, 5 days/week for 4 weeks (20 sessions).
Sponsors
Beijing Rehabilitation Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
40 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1 Age 40–80 years. 2 Imaging evidence of chronic cerebral hypoperfusion (e.g., brain MRI showing white matter hyperintensities, or TCD/CTA indicating cerebral atherosclerosis/stenosis without acute infarction). 3 Subjective complaint of memory decline, with a Montreal Cognitive Assessment (MoCA) score < 26. 4 Clinical Dementia Rating (CDR) = 0.5 (mild). 5 Pharmacological treatment (including cholinesterase inhibitors and/or memantine) has remained stable for at least 3 months prior to enrollment, and the participant agrees not to change the medication regimen throughout the study period.
Exclusion criteria
Exclusion criteria: 1 History of neurodegenerative diseases (e.g., Alzheimer’s disease, Parkinson’s disease, dementia with Lewy bodies), new-onset acute stroke within the past 3 months, brain tumor, traumatic brain injury, or any other neurological disorder that may affect cognition. 2 Severe or unstable systemic diseases (e.g., heart failure, uncontrolled diabetes mellitus, severe infection). 3 Diagnosed major depressive disorder, bipolar disorder, schizophrenia, or other psychiatric disorders that may affect cognition. 4 Presence of metallic implants in the body (e.g., cardiac pacemaker, intracranial metallic implants). 5 History of seizures or uncontrolled epilepsy. 6 Severe skull defect. 7 Severe claustrophobia with inability to tolerate or complete MRI (fMRI) examination.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Auditory Verbal Learning Test (AVLT) total score / delayed recall score;Montreal Cognitive Assessment (MoCA) total score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Trail Making Test (TMT) B–A (time difference);Resting-state EEG band power;Resting-state fMRI hippocampus-to-whole-brain functional connectivity (FC); | — |
Countries
China
Contacts
Public ContactShuyan Qie; Chenye Qiao
Beijing Rehabilitation Hospital, Capital Medical University
Outcome results
None listed