Anal fistula, hemorrhoids, anal fissure, perianal abscess, etc.
Conditions
Interventions
The group of liposomal bupivacaine combined with hydromorphone (trial group):Intrathecal injection of hydromorphone and perianal injection of bupivacaine liposomes
Bupivacain liposomes group (control group):Intracanal injection of bupivacain liposomes
Sponsors
Deyang People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1.Patients who are scheduled to undergo anorectal surgery; 2.Aged 18-60 years old; 3.ASA classification: grade IIII; 4.18<=BMI<=28; 5.Anesthesia method: neuraxial anesthesia; 6.No allergy to study drugs; 7.Voluntary in the experiment with informed consent.
Exclusion criteria
Exclusion criteria: 1.Contraindications to intrathecal puncture; 2.History of psychiatric, neurological diseases; 3.Unable to cooperate with postoperative; 4.History of chronic pain or long-term use of analgesics; 5.Abnormal liver and kidney function (AST >=1.5 ULN,T >=1.5 ULN, Alb = ULN) 6.situations that are not suitable for inclusion as determined by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| QOR-15 score at 24 h, 48 h, 72 h postoperatively; | — |
Secondary
| Measure | Time frame |
|---|---|
| NRS scores at 2 h, 12 h, 36 h, 48 h after operation, at the first dressing change, at first defecation;The time of first rescue with hydromorphone;The amount of hydromorphone rescue at 48 h;The incidence of urinary retention;The time of first flatulence or defecation;The time of first getting out of bed;QOR-15 scores at discharge;Length of hospital stay;Patient satisfaction; | — |
Countries
China
Contacts
Public ContactLiu Li
Deyang People's Hospital
Outcome results
None listed