ARDS
Conditions
Interventions
Control group:Remifentanil 1 mg was diluted with 0.9% sodium chloride solution to a total volume of 50 mL. A loading dose of 0.5–1.0 µg/kg was administered, followed by a continuous intravenous infusi
Trial group:Oxycodone Hydrochloride Injection 40 mg was diluted with 0.9% sodium chloride solution to a total volume of 50 mL. A loading dose of 0.03 mg/kg was administered, followed by a continuous i
Sponsors
Tianjin First Central Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Comply with the new global definition of ARDS in 2023; 2. Mechanical ventilation time > 3d; 3. Hemodynamic stability; 4. Age is 18-70 years old.
Exclusion criteria
Exclusion criteria: 1. Patients with allergies and contraindications to study drugs; 2. Age< 18 years old; 3. Abnormal diaphragmatic function or neuromuscular junction disease in the past or this admission; 4. Pregnant, lactating or terminal malignant tumors; 5. Chronic kidney disease, severe liver dysfunction (Child-Pugh grade C); 6. History of alcohol or drug abuse; 7. Participation in other opioid drug studies within 3 months; 8. Patients who are judged by the investigator to be unsuitable for inclusion in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Respiratory mechanics-related parameters;Respiratory mechanical-related parameters on the first and third days of mechanical ventilation;Diaphragm contraction time and contraction rate;Diaphragmatic rapid breathing index (respiratory rate/diaphragmatic mobility);Rate of change in diaphragm thickness; | — |
Secondary
| Measure | Time frame |
|---|---|
| APACHE?;Dosage of analgesic and sedative medications;Average hourly analgesic dose to achieve analgesic target;Average sedative dose per hour to achieve sedation target;Patient weaning success rate;Duration of mechanical ventilation in surviving patients;Incidence of delirium;ICU time;In-hospital mortality rate; | — |
Countries
China
Contacts
Public ContactYang Shuying
Tianjin First Central Hospital
Outcome results
None listed