Post-operative pain
Conditions
Interventions
Group A:0.2mg of hydromorphone and 0.375% ropivacaine are administered in a total volume of 40ml for bilateral TAPB after the surgery. After completing the TAPB, PCIA is initiated: 8mg of ondansetron
Group B:PCIA after the surgery: 8mg of hydromorphone + 8mg of ondansetron + normal saline (total 100ml), with a constant infusion rate of 2ml/h, a single additional dose of 0.5ml, a lockout time of 1
Sponsors
The Second People’s Hospital of Yibin
Eligibility
Sex/Gender
All
Age
35 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. All participants signed the informed consent form; 2.Age: 35 - 75 years old; 3.American Society of Anesthesiologists (ASA) classification: I - III; 4.Scheduled for laparoscopic surgery, with the operation duration ranging from 1 hour to 4 hours; 5. Preoperative Barthel Index score >= 95 points.
Exclusion criteria
Exclusion criteria: 1. Individuals with mental or psychological disorders; 2. A long history of alcohol and drug abuse, or take sedatives or opioid drugs for a long time; 3. Mini-Mental State Examination (MMSE) score before the surgery indicates the presence of PND (such as patients with Alzheimer's disease); 4. Those who have adverse reactions to the anesthetic drugs used; 5. Those with infection at the puncture site and abnormal coagulation function; 6. Those with diabetes and severe organ dysfunction; 7. Those who refuse to participate in any part of this study: such as those who refuse to participate in the scoring of each scale before and after the surgery, or those who refuse the anesthesia plan in this study; 8. Those with severe organic lesions (coronary heart disease, second-degree or higher atrioventricular block, bradycardia (HR < 50 beats/min), hypotension (SBP < 90 mmHg), bronchial asthma, severe hypertension, severe blood system dysfunction, liver and kidney function disorders, brain dysfunction, gastric emptying restriction and gastroparesis, patients with significant electrolyte abnormalities).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| NRS score;Number of rescue analgesia administrations within 48 hours post-surgery;Total number of PCIAs and number of effective PCIAs;Incidence of adverse reactions (postoperative respiratory depression, nausea and vomiting, drowsiness, skin itching, etc.); | — |
Secondary
| Measure | Time frame |
|---|---|
| Patients' evaluation of pain relief satisfaction 48 hours after surgery;Postoperative first time out of bed for two groups; | — |
Countries
China
Contacts
Public ContactYang Li
The Second People’s Hospital of Yibin
Outcome results
None listed